The process of digital transformation of enterprises is associated with the organization of manufacturing and business processes within the framework of selected types of business models and digital platforms, the distribution and economic substantiation of the roles of participants in network interactions, and ensuring the semantic interoperability of their interaction. Currently, certain experience has been accumulated in the implementation of modern business models for the digital transformation of enterprises which is reflected in the concepts of the Industrie 4.0, the Industrial Internet of Things, the creation of cyber-physical production systems, smart enterprises and intelligent manufacturing. At the same time, the issues of conceptual modeling of the architecture of digital enterprises, which determines the construction of manufacturing and business processes, and its economic substantiation depending on various factors of the external environment and internal economic potential have not yet been sufficiently researched and developed. All of the foregoing determines the relevance of the work presented here. The purpose of the study was to develop ontological and economic methods for substantiating application scenarios for the digitalization of manufacturing and business processes depending on the selected types of business models and digital platforms. To solve the problem, methods of classification, ontological engineering, activity-based costing and analysis of cash flows of income and expenses are used. The article presents an analysis of enterprise digitalization scenarios depending on the types of manufacturing and business processes, the types of business models and digital platforms used. An ontological model of enterprise digital transformation has been constructed, providing a choice of application scenarios for the digitalization of manufacturing and business processes for various types of business models and digital platforms. An economic model is proposed to justify options for constructing application scenarios for the digitalization of production and business processes depending on the distribution of roles of participants in network interaction using methods of activity-based costing and cash flow analysis.